The Philadelphia Phillies go for the series win when they battle the Seattle Mariners in a key interleague matchup on Tuesday. The Mariners (68-58), who have lost three in a row, are 31-33 on the road this season. The Phillies (72-53), who have won two consecutive games, are 38-21 on their home field in 2025.

First pitch from Citizens Bank Park in Philadelphia is set for 6:45 p.m. ET. The Phillies have won four of the past six meetings with the Mariners. Philadelphia is a -171 favorite on the money line (risk $171 to win $100) in the latest Mariners vs. Phillies odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over-under, is 8 in the latest MLB odds. 

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